What is the dose of carboprost (Hemabate) for treating postpartum hemorrhage?

• A. 500 mcg IM
• B. 250 mcg IM
• C. 100 mcg IM
• D. 200 mcg IM

Answer: (B)

Carboprost (Hemabate) is a medication used to treat postpartum hemorrhage due to uterine atony. The recommended dose for this indication is 250 mcg administered intramuscularly (IM). This dosage is effective in promoting uterine contraction and reducing excessive bleeding following childbirth.

Using a dosage of 250 mcg is supported by clinical guidelines, which emphasize the importance of empirical dosing based on its pharmacological effects. Lower dosages may not provide the necessary efficacy for controlling bleeding, while higher doses could lead to increased risks of side effects without additional therapeutic benefit. Hence, administering 250 mcg is considered the standard practice to ensure the balance between efficacy and safety in managing postpartum hemorrhage.